Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5493908 | 0.81 | GABRA1 (0.38) | GABRA1GABRG2GABRB3KIF11RXRA | |
| SCHEMBL17709956 | 0.77 | KDM4C (0.37) | POLBHCAR2P2RY14NOTUMTTR | |
| SCHEMBL7797061 | 0.75 | AKR1C3 (0.44) | GABRA1GABRG2GABRB3KIF11PDK2 | |
| SCHEMBL30192521 | 0.75 | AKR1C3 (0.44) | GABRA1GABRG2GABRB3KIF11PDK2 | |
| SCHEMBL22926164 | 0.75 | POLB (0.39) | POLBHCAR2TTRRXRAPPARA | |
| SCHEMBL29639646 | 0.75 | POLB (0.39) | POLBHCAR2TTRRXRAPPARA | |
| SCHEMBL2380170 | 0.74 | KIF11 (0.51) | KIF11RXRARXRBRXRGALOX15 | |
| SCHEMBL29171786 | 0.73 | POLB (0.33) | POLBHCAR2P2RY14PPARA | |
| SCHEMBL14450546 | 0.72 | GABRA1 (0.43) | GABRA1GABRG2GABRB3KIF11PPARA | |
| SCHEMBL14450521 | 0.72 | GRB2 (0.41) | GABRA1GABRG2GABRB3TTRALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070161542-A1 | Ptb1b photoprobes | RAMACHANDRAN CHIDAMBARAM | 2007-07-12 | — | — | US | disclosed |
| US-20070161542-A1 | Ptb1b photoprobes | RAMACHANDRAN CHIDAMBARAM | 2007-07-12 | — | — | US | disclosed |
| US-20070161542-A1 | Ptb1b photoprobes | RAMACHANDRAN CHIDAMBARAM | 2007-07-12 | — | — | US | disclosed |
| WO-2005056582-A1 | PTP1B PHOTOPROBES | MERCK FROSST CANADA LTD. (CA) | 2005-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161542-A1 | Ptb1b photoprobes | PTBP1, PTBP3, PPP1R1B | POLB 778/4885HCAR2 4718/4885GABRA1 2397/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.