Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | CES2 | O00748 | 2/20 | 0.46 |
| ▸ | CES1 | P23141 | 2/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30309190 | 0.92 | LMNA (0.52) | LMNACES2CES1PGRADRA2A | |
| SCHEMBL8507553 | 0.82 | CES2 (0.49) | CES2CES1PGRADRA2AADRA2B | |
| SCHEMBL19318480 | 0.80 | PGR (0.48) | LMNACES2CES1PGRADRA2A | |
| SCHEMBL7432353 | 0.80 | PGR (0.48) | LMNACES2CES1PGRADRA2A | |
| SCHEMBL8228098 | 0.80 | PGR (0.48) | LMNACES2CES1PGRADRA2A | |
| Hydrochloric Acid SCHEMBL10728681 | 0.79 | MAPT (0.49) | LMNACES2CES1PGRADRA2A | |
| Hydrochloric Acid SCHEMBL10728669 | 0.79 | MAPT (0.49) | LMNACES2CES1PGRADRA2A | |
| SCHEMBL11499402 | 0.76 | PTGS2 (0.50) | LMNAHTR2AMAPTMAPK1ALDH1A1 | |
| SCHEMBL11499403 | 0.76 | PTGS2 (0.50) | LMNAHTR2AMAPTMAPK1ALDH1A1 | |
| Dealkylated Diethylpropion SCHEMBL25176894 | 0.76 | TDP1 (0.52) | LMNACES2CES1PGRADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1754705-A2 | Antagonists for treatment of CD11/CD18 adhesion receptor mediated disorders | Genentech, Inc. (US) | 2007-02-21 | — | — | EP | disclosed |
| EP-1063982-B1 | ANTAGONISTS FOR TREATMENT OF CD11/CD18 ADHESION RECEPTOR MEDIATED DISORDERS | GENENTECH INC (US) | 2007-02-14 | — | — | EP | disclosed |