Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.46 |
| ▸ | PLA2G7 | Q13093 | 4/20 | 0.44 |
| ▸ | ESRRA | P11474 | 1/20 | 0.43 |
| ▸ | PFKFB2 | O60825 | 3/20 | 0.42 |
| ▸ | PFKFB1 | P16118 | 3/20 | 0.42 |
| ▸ | PFKFB3 | Q16875 | 3/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.41 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.41 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4171293 | 0.87 | MTNR1B (0.58) | MTNR1BMTNR1APLA2G7ESRRAPFKFB2 | |
| SCHEMBL4181443 | 0.81 | AR (0.72) | ARSLC22A12CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL17536366 | 0.76 | MTNR1B (0.63) | ARMTNR1BMTNR1APFKFB2PFKFB1 | |
| SCHEMBL17536369 | 0.75 | MTNR1B (0.56) | MTNR1BMTNR1APFKFB2PFKFB1PFKFB3 | |
| SCHEMBL8145133 | 0.72 | MTNR1B (0.74) | MTNR1BMTNR1A | |
| SCHEMBL18615328 | 0.71 | AR (0.60) | ARPLA2G7SLC22A12 | |
| SCHEMBL4171343 | 0.70 | AR (0.59) | ARSLC22A12CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4163780 | 0.69 | AR (0.72) | ARESRRASLC22A12KCNH2 | |
| SCHEMBL4186077 | 0.69 | AR (0.67) | ARSLC22A12CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL28913547 | 0.69 | AR (0.57) | ARPLA2G7SLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781280-A2 | ANDROGEN MODULATORS | Warner-Lambert Company LLC (US) | 2007-05-09 | — | — | EP | claimed |
| WO-2006018723-A2 | ANDROGEN MODULATORS | WARNER-LAMBERT COMPANY LLC (US) | 2006-02-23 | — | — | WO | claimed |