Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.39 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.39 |
| ▸ | ICMT | O60725 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5122808 | 0.81 | MEN1 (0.45) | OPRM1OPRK1OPRL1SIGMAR1SLC6A12 | |
| SCHEMBL5115820 | 0.80 | SLC6A12 (0.52) | OPRM1OPRK1OPRL1SIGMAR1TSHR | |
| SCHEMBL5116631 | 0.78 | DRD4 (0.47) | OPRM1OPRK1OPRL1SIGMAR1TSHR | |
| SCHEMBL5112352 | 0.77 | OPRM1 (0.49) | OPRM1OPRK1OPRL1SIGMAR1TSHR | |
| SCHEMBL14015228 | 0.76 | OPRM1 (0.48) | OPRM1OPRK1OPRL1TSHRACHE | |
| SCHEMBL14015227 | 0.76 | DRD2 (0.51) | OPRM1OPRK1OPRL1SIGMAR1TSHR | |
| SCHEMBL5121438 | 0.76 | DRD4 (0.47) | OPRM1OPRK1OPRL1SIGMAR1ACHE | |
| SCHEMBL5119452 | 0.76 | CHRM4 (0.48) | OPRM1OPRK1OPRL1MCHR1SLC6A12 | |
| SCHEMBL5112789 | 0.74 | OPRD1 (0.51) | OPRM1OPRK1 | |
| SCHEMBL5505695 | 0.74 | CHRM1 (0.39) | ICMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846400-A2 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006074388-A2 | TRICYCLIC δ-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-07-13 | — | — | WO | disclosed |