Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1LG2 | Q9BQ51 | 2/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5505968 | 0.90 | P2RX7 (0.41) | PDCD1LG2CD274KMT2AP2RX7DPP4 | |
| SCHEMBL5500067 | 0.86 | KMT2A (0.36) | PDCD1LG2CD274L3MBTL1KMT2AP2RX7 | |
| SCHEMBL5500736 | 0.80 | KMT2A (0.35) | PDCD1LG2CD274L3MBTL1KMT2AP2RX7 | |
| SCHEMBL5505772 | 0.77 | KMT2A (0.35) | L3MBTL1KMT2AALDH1A1P2RX7HPGD | |
| SCHEMBL5499828 | 0.77 | DPP4 (0.38) | KMT2AP2RX7DPP4DPP8DPP9 | |
| SCHEMBL4130462 | 0.76 | DPP4 (0.38) | L3MBTL1KMT2AP2RX7DPP4DPP8 | |
| SCHEMBL5500031 | 0.75 | P2RX7 (0.44) | KMT2AP2RX7DPP4DPP8DPP9 | |
| SCHEMBL5505217 | 0.74 | P2RX7 (0.37) | KMT2AP2RX7 | |
| SCHEMBL5505679 | 0.74 | P2RX7 (0.44) | KMT2AP2RX7DPP4DPP8DPP9 | |
| SCHEMBL4067724 | 0.74 | HRH3 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006049952-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-05-11 | — | — | WO | disclosed |