Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 7/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5500736 | 0.80 | KMT2A (0.35) | DPP4DPP8DPP9KMT2AP2RX7 | |
| SCHEMBL3941646 | 0.78 | DPP4 (0.37) | DPP4DPP8DPP9OPRL1F10 | |
| SCHEMBL5500067 | 0.78 | KMT2A (0.36) | DPP4DPP8DPP9KMT2AP2RX7 | |
| SCHEMBL5499828 | 0.77 | DPP4 (0.38) | DPP4DPP8DPP9KMT2AP2RX7 | |
| SCHEMBL3946945 | 0.77 | NPY5R (0.40) | DPP4DPP8DPP9OPRL1F10 | |
| SCHEMBL5506138 | 0.76 | P2RX7 (0.46) | DPP4DPP8DPP9KMT2AP2RX7 | |
| SCHEMBL5500075 | 0.76 | PDCD1LG2 (0.35) | DPP4DPP8DPP9KMT2AP2RX7 | |
| SCHEMBL3945085 | 0.73 | CYP11B2 (0.38) | DPP4DPP8DPP9OPRL1NPY5R | |
| SCHEMBL5499762 | 0.71 | P2RX7 (0.42) | DPP4DPP8DPP9KMT2AP2RX7 | |
| SCHEMBL5505772 | 0.71 | KMT2A (0.35) | KMT2AP2RX7L3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049475-A1 | CYCLOHEXYL SUBSTITUTED PYRROLIDINONES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | Eli Lilly & Company (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2007127704-A1 | CYCLOHEXYL SUBSTITUTED PYRROLIDINONES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-11-08 | — | — | WO | disclosed |