Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propoxyphene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 6/20 | 1.00 |
| ▸ | OPRD1 | P41143 | 3/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.98 |
| ▸ | MRGPRX2 | Q96LB1 | 2/20 | 0.98 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.98 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.98 |
| ▸ | HRH2 | P25021 | 1/20 | 0.98 |
| ▸ | HTR2A | P28223 | 1/20 | 0.98 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propoxyphene SCHEMBL5500364 | 1.00 | OPRM1 (1.00) | OPRM1OPRD1KCNH2MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL3425281 | 1.00 | OPRM1 (1.00) | OPRM1OPRD1KCNH2MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL41779 | 1.00 | OPRM1 (1.00) | OPRM1OPRD1KCNH2MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL8717606 | 1.00 | OPRM1 (1.00) | OPRM1OPRD1KCNH2MRGPRX2OPRK1 | |
| Levopropoxyphene SCHEMBL11674402 | 1.00 | OPRM1 (1.00) | OPRM1OPRD1KCNH2MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL6260015 | 0.99 | OPRM1 (0.98) | OPRM1OPRD1KCNH2MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL6263061 | 0.99 | OPRM1 (0.98) | OPRM1OPRD1KCNH2MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL23779946 | 0.99 | OPRM1 (1.00) | OPRM1OPRD1KCNH2MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL8675564 | 0.99 | OPRM1 (1.00) | OPRM1OPRD1KCNH2MRGPRX2OPRK1 | |
| Propoxyphene SCHEMBL16322146 | 0.99 | OPRM1 (1.00) | OPRM1OPRD1KCNH2MRGPRX2OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 8063 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250132388-A1 | ELECTROLYTE FOR LITHIUM SECONDARY BATTERY, AND LITHIUM SECONDARY BATTERY COMPRISING SAME | SAMSUNG SDI CO., LTD. (KR) | 2025-04-24 | — | — | US | claimed |
| WO-2023223216-A1 | SYSTEM FOR ALTERNATING CONCENTRATED MECHANICAL ENERGY | RODRIGUEZ LOPEZ GERSON (MX) | 2023-11-23 | — | — | WO | claimed |
| CN-108267114-B | Auto-collimation total station and working method thereof | 常州市新瑞得仪器有限公司 | 2023-09-26 | — | — | CN | claimed |
| WO-2023167577-A1 | OPTIMISED MICROENCAPSULATED FORMULATION WITH INSECTICIDAL EFFECT AND PROLONGED RELEASE TO BE INCORPORATED INTO PAINT, METHOD FOR FORMING MICROCAPSULES AND PAINT OBTAINED | RIBOT BARROSO JOSE MARIA (MX) | 2023-09-07 | — | — | WO | claimed |
| WO-2023166229-A1 | HERMETIC BARREL PROVIDED WITH A ROTARY DEVICE, WHICH INCLUDES WOOD CHIPS AND AEOLIPIC DISPENSING, FOR AGEING WINES OR SPIRITS AND METHOD FOR USING SAME | TALLEREZ RUIZ, S.A. (ES) | 2023-09-07 | — | — | WO | claimed |
| WO-2023021313-A1 | WATER AND SEED MODIFIER AND ELECTRICITY GENERATION USING WATER AND MAGNETS | HOSSEINI DEHKORDI SEYED HESSAMEDIN (IR) | 2023-02-23 | — | — | WO | claimed |
| WO-2022180441-A1 | FILAMENT PRODUCTION AND RECYCLING MACHINE FOR 3D PRINTERS | KALVAND DARYOUSH (IR) | 2022-09-01 | — | — | WO | claimed |
| EP-3283009-B1 | TRANSCATHETER PROSTHETIC HEART VALVE DELIVERY SYSTEM | MEDTRONIC INC (US) | 2022-06-01 | — | — | EP | claimed |
| EP-2748000-B1 | KIT COMPRISING A PACKAGING MATERIAL AND A SOLID PHARMACEUTICAL OR NUTRACEUTICAL PRODUCT CONTAINED IN THE PACKAGING MATERIAL | SIEGFRIED LTD (CH) | 2020-11-18 | — | — | EP | claimed |
| EP-1898886-B1 | NOVEL SUSTAINED RELEASE DOSAGE FORM | RUBICON RES PVT LTD (IN) | 2019-09-04 | — | — | EP | claimed |
| WO-1985002542-A1 | ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING XANTHINES AND METHODS OF USING SAME | SUNSHINE ABRAHAM | 1985-06-20 | — | — | WO | claimed |
| WO-1985002540-A1 | ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING XANTHINES AND METHODS OF USING SAME | RICHARDSON-VICKS, INC. (US) | 1985-06-20 | — | — | WO | claimed |
| US-4486436-A | Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same | ANALGESIC ASSOCIATES (US) | 1984-12-04 | — | — | US | claimed |
| EP-0114886-A1 | IMPROVED ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING CAFFEINE. | SUNSHINE ABRAHAM (US) | 1984-08-08 | — | — | EP | claimed |
| US-4464376-A | Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same | RICHARDSON-VICKS, INC. (US) | 1984-08-07 | — | — | US | claimed |
| WO-1984000488-A1 | IMPROVED ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING CAFFEINE AND METHODS OF USING SAME | RICHARDSON VICKS INC (US) | 1984-02-16 | — | — | WO | claimed |
| WO-1984000490-A1 | IMPROVED ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING CAFFEINE AND METHODS OF USING SAME | SUNSHINE ABRAHAM | 1984-02-16 | — | — | WO | claimed |
| US-4316884-A | MICROENCAPSULATION, COMPRESSION | ADRIA LABORATORIES, INC. (US) | 1982-02-23 | — | — | US | claimed |
| US-4044125-A | GLUTAMIC ACID, GLYCINE, ASPARTIC ACID, OR ALANINE HYDROCHLORIDE, LYSINE DIHYDROCHLORIDE | ELI LILLY AND COMPANY (US) | 1977-08-23 | — | — | US | claimed |
| US-3936528-A | 2-(6-METHOXY-2-NAPHTHYL)PROPIONIC ACID OR SALT AND CODEINE OR PROPOXYPHENE | SYNTEX CORPORATION (US) | 1976-02-03 | — | — | US | claimed |