Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.52 |
| ▸ | NOS1 | P29475 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | NOS3 | P29474 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL128519 | 0.77 | PLAU (0.55) | PLAUNOS1ALDH1A1HSD17B10ACHE | |
| SCHEMBL3173958 | 0.77 | PLAU (0.59) | PLAUNOS1ALDH1A1HSD17B10ACHE | |
| SCHEMBL3282773 | 0.77 | MEN1 (0.61) | PLAUNOS1ALDH1A1HSD17B10ACHE | |
| SCHEMBL3282776 | 0.77 | MEN1 (0.61) | PLAUNOS1ALDH1A1HSD17B10ACHE | |
| SCHEMBL22567 | 0.75 | ALDH1A1 (0.72) | ALDH1A1HSD17B10ACHELMNACES1 | |
| SCHEMBL27909482 | 0.75 | ALDH1A1 (0.72) | ALDH1A1HSD17B10ACHELMNACES1 | |
| SCHEMBL4365351 | 0.75 | PLAU (0.57) | PLAUNOS1ALDH1A1HSD17B10ACHE | |
| SCHEMBL12155535 | 0.73 | PLAU (0.55) | PLAUNOS1ALDH1A1HSD17B10ACHE | |
| SCHEMBL4168380 | 0.73 | NOS1 (0.59) | PLAUNOS1ALDH1A1HSD17B10ACHE | |
| SCHEMBL128520 | 0.73 | PLAU (0.55) | PLAUNOS1ALDH1A1HSD17B10ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1861378-A1 | N-ARYL-SULFOXIMINE-SUBSTITUTED PYRIMIDINES AS CDK- AND/OR VEGF INHIBITORS, THEIR PRODUCTION AND USE AS PHARMACEUTICAL AGENTS | Bayer Schering Pharma Aktiengesellschaft (DE) | 2007-12-05 | — | — | EP | disclosed |
| WO-2006099974-A1 | N-ARYL-SULFOXIMINE-SUBSTITUTED PYRIMIDINES AS CDK- AND/OR VEGF INHIBITORS, THEIR PRODUCTION AND USE AS PHARMACEUTICAL AGENTS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2006-09-28 | — | — | WO | disclosed |