Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 6/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.56 |
| ▸ | PLAU | P00749 | 1/20 | 0.55 |
| ▸ | NOS3 | P29474 | 4/20 | 0.52 |
| ▸ | NOS2 | P35228 | 2/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.47 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.47 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3173958 | 0.80 | PLAU (0.59) | NOS1ALDH1A1HSD17B10ACHEPLAU | |
| SCHEMBL3282776 | 0.80 | MEN1 (0.61) | NOS1ALDH1A1HSD17B10ACHEPLAU | |
| SCHEMBL3282773 | 0.80 | MEN1 (0.61) | NOS1ALDH1A1HSD17B10ACHEPLAU | |
| SCHEMBL22567 | 0.79 | ALDH1A1 (0.72) | ALDH1A1HSD17B10ACHERECQLMAPK1 | |
| SCHEMBL27909482 | 0.79 | ALDH1A1 (0.72) | ALDH1A1HSD17B10ACHERECQLMAPK1 | |
| SCHEMBL4365351 | 0.78 | PLAU (0.57) | NOS1ALDH1A1HSD17B10ACHEPLAU | |
| SCHEMBL18245160 | 0.77 | NOS1 (0.50) | NOS1ALDH1A1HSD17B10ACHEPLAU | |
| Methyl Alcohol SCHEMBL27456236 | 0.76 | HSD17B10 (0.70) | NOS1ALDH1A1HSD17B10ACHERECQL | |
| SCHEMBL12155535 | 0.76 | PLAU (0.55) | NOS1ALDH1A1HSD17B10ACHEPLAU | |
| SCHEMBL128519 | 0.76 | PLAU (0.55) | NOS1ALDH1A1HSD17B10ACHEPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050080261-A1 | Purine inhibitors of cyclin dependent kinase 2 and IkappaB-alpha | LUM ROBERT T (US) | 2005-04-14 | — | — | US | claimed |
| US-20090105261-A1 | Novel substituted pyrazolo[1,5<I>A</I>]-1,3,5-Triazine derivatives and their analogues, pharmaceutical compositions containing same, use thereof as medicine and methods for preparing same | GREENPHARMA (FR) | 2009-04-23 | — | — | US | disclosed |
| US-7109330-B2 | Purine inhibitors of cyclin dependent kinase 2 and IκB-α | CV THERAPEUTICS, INC. (US) | 2006-09-19 | — | — | US | disclosed |
| US-20060106019-A1 | Novel substituted pyrazolo[1,5 a]-1,3,5-triazine derivatives and their analogues, pharmaceutical compositions containing same, use thereof as medicine and methods for preparing same | GREENPHARMA (FR) | 2006-05-18 | — | — | US | disclosed |
| EP-1150982-B1 | PURINE INHIBITORS OF CYCLIN DEPENDENT KINASE 2 AND IkB-alpha | CV THERAPEUTICS INC (US) | 2005-10-12 | — | — | EP | disclosed |
| EP-1525205-A2 | NOVEL SUBSTITUTED PYRAZOLO( 1,5-A /I ]-1,3,5-TRIAZINE DERIVATIVES AND THEIR ANALOGUES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, USE THEREOF AS MEDICINE AND METHODS FOR PREPARING SAME | Greenpharma (FR) | 2005-04-27 | — | — | EP | disclosed |
| US-20050080261-A1 | Purine inhibitors of cyclin dependent kinase 2 and IkappaB-alpha | LUM ROBERT T (US) | 2005-04-14 | — | — | US | disclosed |
| US-6790958-B2 | ANTIPROLIFERATIVE AGENTS; FUNGICIDES | LUM ROBERT T (US) | 2004-09-14 | — | — | US | disclosed |
| WO-2004011464-A2 | NOVEL SUBSTITUTED PYRAZOLO[1,5 A]-1,3,5-TRIAZINE DERIVATIVES AND THEIR ANALOGUES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, USE THEREOF AS MEDICINE AND METHODS FOR PREPARING SAME | GREENPHARMA (FR) | 2004-02-05 | — | — | WO | disclosed |
| EP-0010001-B1 | PHOTOGRAPHIC RECORDING MATERIAL CONTAINING SHIFTED DYE RELEASING COMPOUND | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1983-08-17 | — | — | EP | disclosed |
| US-4234672-A | GOOD STORAGE STABILITY, BUT UNBLOCK RAPIDLY UNDER PROCESSING CONDITIONS | EASTMAN KODAK COMPANY (US) | 1980-11-18 | — | — | US | disclosed |
| EP-0010001-A2 | Photographic recording material containing shifted dye releasing compound | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1980-04-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050080261-A1 | Purine inhibitors of cyclin dependent kinase 2 and IkappaB-alpha | IKBKB, NFKB1, CDK4 | NOS1 3826/4885ALDH1A1 3492/4885HSD17B10 2917/4885 |
| US-20060106019-A1 | Novel substituted pyrazolo[1,5 a]-1,3,5-triazine derivatives and their analogues, pharmaceutical compositions containing same, use thereof as medicine and methods for preparing same | PMP22, BDNF, GRIK5 | NOS1 1163/4885ALDH1A1 312/4885HSD17B10 1798/4885 |
| US-20090105261-A1 | Novel substituted pyrazolo[1,5<I>A</I>]-1,3,5-Triazine derivatives and their analogues, pharmaceutical compositions containing same, use thereof as medicine and methods for preparing same | BDNF, NTRK2, NGF | NOS1 256/4885ALDH1A1 424/4885HSD17B10 3999/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.