Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 4/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.36 |
| ▸ | ABL1 | P00519 | 7/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.33 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5506180 | 0.86 | AAK1 (0.34) | PDCD1LG2CD274 | |
| Hydrochloric Acid SCHEMBL5499646 | 0.85 | AAK1 (0.33) | PDCD1LG2CD274 | |
| SCHEMBL5499996 | 0.85 | CNR1 (0.38) | CYP11B2CYP11B1JAK2 | |
| Hydrochloric Acid SCHEMBL5504549 | 0.84 | CNR1 (0.38) | CYP11B2CYP11B1JAK2 | |
| SCHEMBL5503224 | 0.84 | CTSS (0.35) | BTKJAK2JAK1JAK3 | |
| SCHEMBL5506352 | 0.83 | BTK (0.32) | BTKPDCD1LG2CD274JAK2JAK1 | |
| SCHEMBL5506141 | 0.83 | CD38 (0.35) | PDCD1LG2CD274JAK2JAK1JAK3 | |
| SCHEMBL5499853 | 0.83 | SCN9A (0.37) | SCN9APDCD1LG2CD274JAK1 | |
| SCHEMBL5509832 | 0.83 | NPY5R (0.41) | CYP11B2PDCD1LG2CD274JAK2JAK1 | |
| SCHEMBL5502844 | 0.83 | PDCD1LG2 (0.35) | PDCD1LG2CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-07-18 | — | — | EP | claimed |
| WO-2006049952-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-05-11 | — | — | WO | claimed |