Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 4/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | JAK1 | P23458 | 3/20 | 0.31 |
| ▸ | JAK3 | P52333 | 3/20 | 0.31 |
| ▸ | HTR2A | P28223 | 2/20 | 0.31 |
| ▸ | HTR2C | P28335 | 2/20 | 0.31 |
| ▸ | HTR2B | P41595 | 2/20 | 0.31 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.31 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
| ▸ | SYK | P43405 | 2/20 | 0.30 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5504552 | 0.84 | NPY5R (0.34) | JAK2JAK1JAK3HTR2AHTR2C | |
| SCHEMBL5501522 | 0.83 | CYP11B2 (0.36) | BTKJAK2JAK1JAK3PDCD1LG2 | |
| SCHEMBL5503778 | 0.83 | CTSS (0.35) | JAK2JAK1JAK3HTR2AHTR2C | |
| SCHEMBL5509832 | 0.82 | NPY5R (0.41) | JAK2JAK1JAK3PDCD1LG2CD274 | |
| SCHEMBL5506180 | 0.82 | AAK1 (0.34) | PDCD1LG2CD274P2RX7NPY5R | |
| Hydrochloric Acid SCHEMBL5506013 | 0.81 | NPY5R (0.40) | JAK2JAK1JAK3PDCD1LG2CD274 | |
| Hydrochloric Acid SCHEMBL5499646 | 0.81 | AAK1 (0.33) | PDCD1LG2CD274P2RX7NPY5R | |
| SCHEMBL5506470 | 0.81 | NPY5R (0.40) | PDCD1LG2CD274P2RX7NPY5R | |
| SCHEMBL5502844 | 0.80 | PDCD1LG2 (0.35) | PDCD1LG2CD274P2RX7SYKNPY5R | |
| SCHEMBL5500736 | 0.80 | KMT2A (0.35) | PDCD1LG2CD274P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-07-18 | — | — | EP | claimed |
| WO-2006049952-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-05-11 | — | — | WO | claimed |