Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | CD38 | P28907 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 2/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5499996 | 0.86 | CNR1 (0.38) | JAK2CYP3A4CYP2C9DYRK1AHCRTR1 | |
| SCHEMBL5506180 | 0.86 | AAK1 (0.34) | CTSSHSD11B1CD38NPY5RP2RX7 | |
| Hydrochloric Acid SCHEMBL5504549 | 0.85 | CNR1 (0.38) | JAK2CYP3A4CYP2C9DYRK1AHCRTR1 | |
| Hydrochloric Acid SCHEMBL5499646 | 0.85 | AAK1 (0.33) | CTSSHSD11B1CD38NPY5RP2RX7 | |
| SCHEMBL5503778 | 0.85 | CTSS (0.35) | CTSSJAK2JAK1JAK3SYK | |
| SCHEMBL5506470 | 0.85 | NPY5R (0.40) | CD38NPY5RP2RX7 | |
| SCHEMBL5506141 | 0.85 | CD38 (0.35) | CTSSJAK2JAK1JAK3CD38 | |
| SCHEMBL5504552 | 0.84 | NPY5R (0.34) | CTSSJAK2JAK1JAK3CD38 | |
| SCHEMBL5501522 | 0.84 | CYP11B2 (0.36) | JAK2JAK1JAK3BTK | |
| SCHEMBL5500821 | 0.84 | CNR1 (0.38) | JAK2CYP3A4CYP2C9DYRK1ANPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-07-18 | — | — | EP | claimed |
| WO-2006049952-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-05-11 | — | — | WO | claimed |