Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | EED | O75530 | 1/20 | 0.35 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5500660 | 0.79 | F10 (0.33) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL5500662 | 0.79 | F10 (0.33) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL5504616 | 0.77 | LMNA (0.44) | P2RX7ALDH1A1LMNAKMT2AMAPT | |
| SCHEMBL5499906 | 0.77 | LMNA (0.44) | P2RX7ALDH1A1LMNAKMT2AMAPT | |
| SCHEMBL5501783 | 0.77 | LMNA (0.43) | P2RX7ALDH1A1LMNAKMT2AMAPT | |
| SCHEMBL5499654 | 0.76 | LMNA (0.43) | P2RX7ALDH1A1LMNAKMT2AMAPT | |
| SCHEMBL5502921 | 0.76 | GRM2 (0.35) | — | |
| SCHEMBL5500515 | 0.76 | P2RX7 (0.42) | P2RX7LMNAKMT2ASMN1; SMN2POLB | |
| SCHEMBL5505772 | 0.74 | KMT2A (0.35) | P2RX7ALDH1A1LMNAKMT2AKDM4E | |
| SCHEMBL5503369 | 0.74 | LMNA (0.43) | P2RX7ALDH1A1LMNAKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006049952-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-05-11 | — | — | WO | disclosed |