Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.39 |
| ▸ | WNT3A | P56704 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | RORB | Q92753 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2871268 | 0.83 | GAA (0.42) | GAAKDM4EALDH1A1CTNNB1WNT3A | |
| SCHEMBL1880217 | 0.82 | LMNA (0.46) | GAAKDM4EALDH1A1CTNNB1WNT3A | |
| SCHEMBL3127871 | 0.80 | BCAT2 (0.46) | GAAKDM4EALDH1A1CTNNB1WNT3A | |
| SCHEMBL9443949 | 0.80 | GSK3B (0.43) | GAAKDM4EALDH1A1GSK3BHPGD | |
| Hydrochloric Acid SCHEMBL18131143 | 0.80 | LMNA (0.44) | GAAKDM4EALDH1A1CTNNB1WNT3A | |
| SCHEMBL10328560 | 0.80 | ALDH1A1 (0.43) | GAAKDM4EALDH1A1CTNNB1WNT3A | |
| SCHEMBL1031987 | 0.77 | DHODH (0.43) | GAAKDM4EALDH1A1CTNNB1WNT3A | |
| SCHEMBL20825514 | 0.76 | KMT2A (0.50) | GAAKDM4EALDH1A1HPGDLMNA | |
| SCHEMBL27938634 | 0.74 | ALDH1A1 (0.49) | GAAKDM4EALDH1A1CTNNB1WNT3A | |
| SCHEMBL617309 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740547-A1 | PGD2 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005100321-A1 | PGD2 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-10-27 | — | — | WO | disclosed |