Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 10/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | TACR1 | P25103 | 2/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.33 |
| ▸ | CACNG8 | Q8WXS5 | 3/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | CACNG2 | Q9Y698 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.32 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5493839 | 0.93 | P2RX7 (0.39) | P2RX7SLC6A2SLC6A4KCNH2CYP2D6 | |
| SCHEMBL5502120 | 0.87 | SLC6A2 (0.38) | SLC6A2SLC6A4KCNH2CYP2D6SLC6A3 | |
| SCHEMBL5495138 | 0.84 | KCNH2 (0.37) | P2RX7SLC6A2SLC6A4KCNH2CYP2D6 | |
| SCHEMBL5500092 | 0.82 | FFAR4 (0.43) | P2RX7SLC6A2SLC6A4KCNH2TACR1 | |
| SCHEMBL5499318 | 0.80 | KCNH2 (0.33) | P2RX7SLC6A2SLC6A4KCNH2CYP2D6 | |
| SCHEMBL5500299 | 0.80 | TAAR1 (0.42) | SLC6A2SLC6A4KCNH2CYP2D6SLC6A3 | |
| SCHEMBL5495230 | 0.77 | EPHX1 (0.39) | KCNH2TACR1FFAR4 | |
| SCHEMBL5501435 | 0.76 | KCNH2 (0.38) | P2RX7SLC6A2SLC6A4KCNH2CYP2D6 | |
| SCHEMBL5493818 | 0.75 | FFAR4 (0.41) | SLC6A2SLC6A4KCNH2SLC6A3TACR1 | |
| SCHEMBL5499300 | 0.74 | SLC6A2 (0.45) | P2RX7SLC6A2SLC6A4KCNH2TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765779-A1 | NEW SUBSTITUTED PIPERIDINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005121092-A1 | NEW SUBSTITUTED PIPERIDINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2005-12-22 | — | — | WO | disclosed |