Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 5/20 | 0.35 |
| ▸ | DRD3 | P35462 | 3/20 | 0.35 |
| ▸ | HTR1A | P08908 | 5/20 | 0.34 |
| ▸ | HTR7 | P34969 | 5/20 | 0.34 |
| ▸ | RBP4 | P02753 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | INSR | P06213 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5502367 | 0.86 | DRD2 (0.45) | DRD2CCR5KMT2AALDH1A1GAA | |
| SCHEMBL2783837 | 0.82 | DRD2 (0.45) | DRD2CCR5KMT2AHTR6DRD3 | |
| SCHEMBL2782438 | 0.78 | DRD3 (0.45) | DRD2KMT2AALDH1A1GAAL3MBTL1 | |
| SCHEMBL5514024 | 0.76 | DRD2 (0.34) | DRD2HTR6DRD3HTR1AHTR7 | |
| SCHEMBL2784338 | 0.75 | DRD2 (0.50) | DRD2KMT2ADRD3RBP4MEN1 | |
| SCHEMBL5499969 | 0.75 | HTR1A (0.36) | DRD2HTR6DRD3HTR1AHTR7 | |
| SCHEMBL2782202 | 0.74 | DRD2 (0.56) | DRD2KMT2AHTR6DRD3MEN1 | |
| SCHEMBL2782241 | 0.72 | RBP4 (0.42) | DRD2HTR6DRD3HTR1AHTR7 | |
| SCHEMBL27684027 | 0.72 | RBP4 (0.41) | DRD2KMT2AHTR6DRD3HTR1A | |
| SCHEMBL27684024 | 0.72 | RBP4 (0.45) | DRD2DRD3HTR1AHTR7RBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773772-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2007-04-18 | — | — | EP | disclosed |
| WO-2005121087-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2005-12-22 | — | — | WO | disclosed |