Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 3/20 | 0.41 |
| ▸ | HTR6 | P50406 | 3/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | RBP4 | P02753 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2783837 | 0.96 | DRD2 (0.45) | DRD2KMT2ADRD3HTR6HTR1A | |
| SCHEMBL2782438 | 0.91 | DRD3 (0.45) | DRD2KMT2AALDH1A1GAAL3MBTL1 | |
| SCHEMBL2782202 | 0.87 | DRD2 (0.56) | DRD2KMT2ADRD3HTR6MEN1 | |
| SCHEMBL5502371 | 0.86 | DRD2 (0.37) | DRD2KMT2AALDH1A1GAAL3MBTL1 | |
| SCHEMBL2782906 | 0.84 | DRD2 (0.46) | DRD2KMT2ADRD3HTR6HTR1A | |
| SCHEMBL2783439 | 0.84 | DRD2 (0.46) | DRD2KMT2ADRD3HTR6HTR1A | |
| SCHEMBL2784338 | 0.83 | DRD2 (0.50) | DRD2KMT2ADRD3RBP4MEN1 | |
| Ordopidine SCHEMBL5506147 | 0.82 | HTR6 (0.38) | DRD2KMT2ADRD3HTR6HRH3 | |
| SCHEMBL28761287 | 0.81 | DRD2 (0.44) | DRD2KMT2ADRD3HTR6HTR1A | |
| SCHEMBL2782241 | 0.80 | RBP4 (0.42) | DRD2DRD3HTR6HTR1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773772-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2007-04-18 | — | — | EP | disclosed |
| WO-2005121087-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2005-12-22 | — | — | WO | disclosed |