Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 2/20 | 0.41 |
| ▸ | NOS1 | P29475 | 2/20 | 0.41 |
| ▸ | NOS2 | P35228 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | RBP4 | P02753 | 2/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.39 |
| ▸ | DRD3 | P35462 | 3/20 | 0.39 |
| ▸ | HTR6 | P50406 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3772743 | 0.93 | NOS3 (0.46) | NOS3NOS1NOS2DRD4RBP4 | |
| SCHEMBL2783029 | 0.93 | DRD4 (0.45) | NOS3NOS1NOS2DRD4DRD3 | |
| SCHEMBL5506659 | 0.87 | PGR (0.39) | NOS3NOS1NOS2DRD4RBP4 | |
| SCHEMBL2783674 | 0.83 | DRD2 (0.54) | DRD4DRD3HTR6HRH3DRD2 | |
| SCHEMBL2782347 | 0.83 | DRD2 (0.54) | NOS3NOS1NOS2DRD4DRD3 | |
| SCHEMBL2783316 | 0.81 | DRD4 (0.46) | NOS3NOS1NOS2DRD4DRD3 | |
| SCHEMBL2781201 | 0.80 | DRD4 (0.47) | NOS3NOS1NOS2DRD4DRD3 | |
| SCHEMBL14163184 | 0.79 | DRD4 (0.54) | NOS3NOS1NOS2DRD4GRM2 | |
| SCHEMBL3759922 | 0.78 | DRD4 (0.48) | NOS3NOS1NOS2DRD4DRD3 | |
| SCHEMBL3772538 | 0.78 | HTR6 (0.40) | NOS3NOS1NOS2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1768958-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES AS MODULATORS OF DOPAMINE AND SEROTONIN NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2007-04-04 | — | — | EP | disclosed |
| WO-2005121088-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES AS MODULATORS OF DOPAMINE AND SEROTONIN NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2005-12-22 | — | — | WO | disclosed |