Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 18/20 | 0.66 |
| ▸ | KLKB1 | P03952 | 7/20 | 0.66 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL392453 | 0.79 | F11 (1.00) | F11KLKB1 | |
| SCHEMBL392454 | 0.79 | F11 (1.00) | F11KLKB1 | |
| SCHEMBL5499169 | 0.71 | NOTUM (0.50) | F11KLKB1 | |
| SCHEMBL8599433 | 0.67 | ALDH1A1 (0.69) | F11 | |
| SCHEMBL8599432 | 0.67 | ALDH1A1 (0.69) | F11 | |
| Hydrochloric Acid SCHEMBL3794359 | 0.66 | ALDH1A1 (0.68) | F11 | |
| Hydrochloric Acid SCHEMBL8595569 | 0.66 | ALDH1A1 (0.68) | F11 | |
| SCHEMBL23619652 | 0.65 | F11 (0.57) | F11KLKB1 | |
| SCHEMBL15679868 | 0.65 | POLB (0.64) | — | |
| SCHEMBL2105730 | 0.64 | F11 (1.00) | F11KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773786-A2 | FIVE-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2005123050-A2 | FIVE-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |