Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.38 |
| ▸ | AHR | P35869 | 2/20 | 0.36 |
| ▸ | CMA1 | P23946 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | CES1 | P23141 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | TGM2 | P21980 | 1/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.31 |
| ▸ | GABRP | O00591 | 1/20 | 0.30 |
| ▸ | GABRD | O14764 | 1/20 | 0.30 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7982185 | 0.82 | MEN1 (0.48) | AHRMEN1KMT2AMAPTMAPK13 | |
| SCHEMBL1290778 | 0.80 | SMYD3 (0.36) | MEN1KMT2A | |
| SCHEMBL1290780 | 0.73 | ITGB3 (0.31) | MEN1KMT2AMAPT | |
| SCHEMBL31332320 | 0.72 | CA12 (0.36) | AHRCMA1KMT2ACA12CA2 | |
| SCHEMBL1319879 | 0.72 | AHR (0.55) | CHEK1AHRCMA1MEN1KMT2A | |
| SCHEMBL30509190 | 0.65 | AHR (0.55) | CHEK1AHRCMA1MEN1KMT2A | |
| SCHEMBL11463464 | 0.65 | AHR (0.55) | CHEK1AHRCMA1MEN1KMT2A | |
| SCHEMBL29532858 | 0.65 | CHEK1 (0.49) | CHEK1AHRCMA1MEN1KMT2A | |
| SCHEMBL3522841 | 0.65 | CHEK1 (0.49) | CHEK1AHRCMA1MEN1KMT2A | |
| SCHEMBL28552531 | 0.64 | AHR (0.50) | AHRMEN1KMT2ACES1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756070-A2 | CRYSTALLINE FORMS OF N-DESMETHYLCLOZAPINE | Acadia Pharmaceuticals Inc. (US) | 2007-02-28 | — | — | EP | disclosed |
| WO-2006001866-A2 | CRYSTALLINE FORMS OF N-DESMETHYLCLOZAPINE | ACADIA PHARMACEUTICALS INC. (US) | 2006-01-05 | — | — | WO | disclosed |