Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.45 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.44 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 4/20 | 0.43 |
| ▸ | BCHE | P06276 | 2/20 | 0.43 |
| ▸ | LTA4H | P09960 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5507813 | 0.90 | CHRM4 (0.43) | OPRM1OPRK1OPRL1SLC6A12SLC6A13 | |
| SCHEMBL5505687 | 0.87 | OPRM1 (0.45) | OPRM1OPRK1OPRL1ACHEMAPT | |
| SCHEMBL5503522 | 0.85 | P2RX4 (0.46) | MAPT | |
| SCHEMBL5115820 | 0.85 | SLC6A12 (0.52) | OPRM1OPRK1OPRL1SLC6A12SLC6A13 | |
| SCHEMBL5506035 | 0.85 | KDM4E (0.47) | SLC6A12ALDH1A1SIGMAR1 | |
| SCHEMBL5509159 | 0.82 | DRD4 (0.43) | OPRM1OPRK1OPRL1ACHETSHR | |
| SCHEMBL5506807 | 0.79 | DRD4 (0.44) | OPRM1OPRK1OPRL1ACHEMAPT | |
| SCHEMBL5505147 | 0.78 | KDM4E (0.45) | SLC6A12ALDH1A1SIGMAR1 | |
| SCHEMBL5119452 | 0.77 | CHRM4 (0.48) | OPRM1OPRK1OPRL1SLC6A12SLC6A13 | |
| SCHEMBL5112789 | 0.76 | OPRD1 (0.51) | OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846400-A2 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-24 | — | — | EP | claimed |
| WO-2006074388-A2 | TRICYCLIC δ-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-07-13 | — | — | WO | claimed |
| EP-1846400-A2 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006074388-A2 | TRICYCLIC δ-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-07-13 | — | — | WO | disclosed |