Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX4 | Q99571 | 4/20 | 0.46 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | SCN1A | P35498 | 1/20 | 0.33 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.33 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.33 |
| ▸ | OXTR | P30559 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5507953 | 0.89 | P2RX4 (0.46) | P2RX4MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL5503754 | 0.85 | OPRM1 (0.45) | MAPT | |
| SCHEMBL5120140 | 0.84 | P2RX4 (0.49) | P2RX4KDM2BMEN1KMT2AMAPT | |
| SCHEMBL5507813 | 0.78 | CHRM4 (0.43) | MEN1KMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL5503010 | 0.76 | PIM1 (0.38) | P2RX4MAPTSMN1; SMN2NPSR1 | |
| SCHEMBL5115161 | 0.75 | P2RX4 (0.49) | P2RX4MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL5506035 | 0.73 | KDM4E (0.47) | MEN1KMT2AOXTR | |
| SCHEMBL5125316 | 0.72 | OPRD1 (0.45) | P2RX4 | |
| SCHEMBL5505687 | 0.71 | OPRM1 (0.45) | MEN1KMT2AMAPTDRD2DRD4 | |
| SCHEMBL5118932 | 0.71 | NPC1 (0.43) | P2RX4SMN1; SMN2OXTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846400-A2 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-24 | — | — | EP | claimed |
| WO-2006074388-A2 | TRICYCLIC δ-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-07-13 | — | — | WO | claimed |
| EP-1846400-A2 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006074388-A2 | TRICYCLIC δ-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-07-13 | — | — | WO | disclosed |