Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 7/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.38 |
| ▸ | GRK3 | P35626 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28521875 | 0.85 | HDAC1 (0.49) | CNR1HDAC1HDAC8NPSR1LIPG | |
| SCHEMBL18240882 | 0.82 | IDO1 (0.44) | CNR1HDAC1HDAC8NPSR1DAO | |
| SCHEMBL6009979 | 0.81 | MPO (0.51) | SLC2A1CNR1 | |
| SCHEMBL10278379 | 0.77 | ADRB2 (0.41) | CNR1HDAC1HDAC8SCN8ANPSR1 | |
| SCHEMBL353164 | 0.76 | NQO2 (0.55) | SLC2A1 | |
| SCHEMBL5503261 | 0.74 | MEN1 (0.47) | CNR1HDAC1HDAC8NPSR1KDM4E | |
| SCHEMBL5544075 | 0.74 | CNR1 (0.48) | CNR1HDAC1HDAC8SCN8ALIPG | |
| SCHEMBL28546770 | 0.74 | HDAC1 (0.50) | CNR1HDAC1HDAC8NPSR1LIPG | |
| SCHEMBL5500210 | 0.73 | KDM4E (0.49) | CNR1HDAC1HDAC8SCN8ANR3C2 | |
| SCHEMBL2879992 | 0.72 | AKR1B1 (0.50) | HDAC1HDAC8NPSR1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828111-A2 | METHODS AND FLUORINATED COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES | Neurochem (International) Limited (CH) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006059252-A2 | METHODS AND FLUORINATED COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2006-06-08 | — | — | WO | disclosed |