Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | RORC | P51449 | 3/20 | 0.44 |
| ▸ | RORB | Q92753 | 3/20 | 0.44 |
| ▸ | CTSD | P07339 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | STS | P08842 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1623334 | 0.84 | MAPT (0.46) | LMNAALOX15HSD17B10MAPTRORC | |
| SCHEMBL13362727 | 0.79 | ALDH1A1 (0.44) | ALOX15HSD17B10MAPTHTT | |
| SCHEMBL1516803 | 0.77 | LMNA (0.48) | LMNAALOX15HSD17B10MAPTRORC | |
| SCHEMBL264288 | 0.77 | IRAK4 (0.63) | LMNAMAPTCTSDNPC1RAB9A | |
| SCHEMBL29423358 | 0.77 | IRAK4 (0.63) | LMNAMAPTCTSDNPC1RAB9A | |
| SCHEMBL29658169 | 0.76 | CTSD (0.62) | LMNAALOX15HSD17B10CTSDNPC1 | |
| SCHEMBL322168 | 0.76 | CTSD (0.62) | LMNAALOX15HSD17B10CTSDNPC1 | |
| Hydrochloric Acid SCHEMBL4374712 | 0.75 | IRAK4 (0.61) | LMNAMAPTCTSDNPC1RAB9A | |
| SCHEMBL4881322 | 0.75 | IRAK4 (0.61) | LMNAMAPTCTSDNPC1RAB9A | |
| SCHEMBL31174577 | 0.75 | IRAK4 (0.61) | LMNAMAPTCTSDNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784393-A1 | QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS | Vertex Pharmaceuticals Incorporated (US) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006028904-A1 | QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-03-16 | — | — | WO | disclosed |