Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.35 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | CHKA | P35790 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24112344 | 0.82 | ADAM17 (0.47) | SIGMAR1RAB9AADAM17CASP6MMP1 | |
| SCHEMBL11064005 | 0.81 | SIGMAR1 (0.51) | SIGMAR1CHRM5CHRM3OPRD1CYP1A2 | |
| SCHEMBL28340601 | 0.79 | OPRD1 (0.40) | SIGMAR1CHRM5CHRM3RAB9ACASP6 | |
| SCHEMBL18289817 | 0.79 | RAB9A (0.58) | SIGMAR1CHRM5CHRM3RAB9AOPRD1 | |
| SCHEMBL28880171 | 0.79 | RAB9A (0.58) | SIGMAR1CHRM5CHRM3RAB9AOPRD1 | |
| SCHEMBL10633804 | 0.77 | RAB9A (0.39) | SIGMAR1CHRM5CHRM3RAB9AOPRD1 | |
| SCHEMBL28912998 | 0.73 | RAB9A (0.47) | SIGMAR1CHRM5CHRM3RAB9AOPRD1 | |
| SCHEMBL5488766 | 0.73 | OPRD1 (0.38) | SIGMAR1CHRM5CHRM3OPRD1CA2 | |
| SCHEMBL18289932 | 0.73 | RAB9A (0.51) | SIGMAR1CHRM5CHRM3RAB9ACASP6 | |
| Hydrochloric Acid SCHEMBL4974751 | 0.71 | OPRD1 (0.38) | SIGMAR1CHRM5CHRM3OPRD1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788351-A1 | SUBSTITUTED 3,4-DIHYDROPYRROLO[1,2-a]PYRAZIN-1(2H)-ONE DERIVATIVES AS KINASES INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2014-10-15 | — | — | EP | disclosed |
| WO-2013050446-A1 | SUBSTITUTED 3,4-DIHYDROPYRROLO[1,2-a]PYRAZIN-1(2H)-ONE DERIVATIVES AS KINASES INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2013-04-11 | — | — | WO | disclosed |
| EP-1861376-A1 | CIS-2,4,5-TRIARYL-IMIDAZOLINES AND THEIR USE AS ANTI-CANCER MEDICAMENTS | F. Hoffmann-Roche AG (CH) | 2007-12-05 | — | — | EP | disclosed |
| WO-2006097261-A1 | CIS-2,4,5-TRIARYL-IMIDAZOLINES AND THEIR USE AS ANTI-CANCER MEDICAMENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-09-21 | — | — | WO | disclosed |