Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CCR3 | P51677 | 1/20 | 0.36 |
| ▸ | PRCP | P42785 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5506511 | 0.90 | DRD2 (0.46) | DRD2DRD4ACHEKDM1AMAPT | |
| SCHEMBL5115110 | 0.86 | DRD2 (0.47) | DRD2DRD4ACHEKDM1AMAPT | |
| SCHEMBL5504518 | 0.84 | KDM1A (0.40) | ACHEKDM1AMAPTCCR3HTR2A | |
| SCHEMBL5512320 | 0.82 | HRH3 (0.41) | DRD2DRD4KDM1AHRH3HTR2A | |
| SCHEMBL5507199 | 0.82 | DRD2 (0.43) | DRD2DRD4ACHEMAPTCCR3 | |
| SCHEMBL5116584 | 0.76 | DRD2 (0.49) | DRD2DRD4ACHEKDM1AMAPT | |
| SCHEMBL5505604 | 0.73 | DRD2 (0.46) | DRD2DRD4ACHEMAPTCCR3 | |
| SCHEMBL5115279 | 0.72 | ACHE (0.44) | DRD2ACHEKDM1AMAPTCCR3 | |
| SCHEMBL5509159 | 0.72 | DRD4 (0.43) | DRD2DRD4ACHE | |
| SCHEMBL5115251 | 0.71 | DRD2 (0.47) | DRD2DRD4ACHEMAPTCCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846400-A2 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-24 | — | — | EP | claimed |
| WO-2006074388-A2 | TRICYCLIC δ-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-07-13 | — | — | WO | claimed |
| EP-1846400-A2 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006074388-A2 | TRICYCLIC δ-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-07-13 | — | — | WO | disclosed |