SCHEMBL5504518

SCHEMBL5504518

Oc1cc(Br)cc2c1N(C1CCN(CCc3ccccc3)CC1)c1ccccc1S2

nearest known ligand 0.46

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 2/20 0.40
MAPT P10636 1/20 0.40
ACHE P22303 1/20 0.40
CCR3 P51677 1/20 0.39
HTR2A P28223 2/20 0.38
KDM4E B2RXH2 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2D6 P10635 1/20 0.38
TSHR P16473 1/20 0.38
HTR2C P28335 1/20 0.38
OPRM1 P35372 1/20 0.38
OPRK1 P41145 1/20 0.38
OPRL1 P41146 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5115279 0.84 ACHE (0.44) KDM1AMAPTACHECCR3HTR2A
SCHEMBL5504478 0.84 CYP2D6 (0.41) KDM1AHTR2ACYP1A2CYP3A4CYP2D6
SCHEMBL5504474 0.84 DRD2 (0.43) KDM1AMAPTACHECCR3HTR2A
SCHEMBL5506511 0.82 DRD2 (0.46) KDM1AMAPTACHE
SCHEMBL5505801 0.80 DRD4 (0.46) KDM1AMAPTKDM4E
SCHEMBL5506174 0.79 KDM1A (0.35) KDM1AHTR2AHTR2C
SCHEMBL5115110 0.72 DRD2 (0.47) KDM1AMAPTACHECCR3OPRM1
SCHEMBL5116584 0.70 DRD2 (0.49) KDM1AMAPTACHECCR3OPRM1
SCHEMBL5111729 0.69 NPC1 (0.49) HTR2AKDM4EOPRM1OPRK1
SCHEMBL5508467 0.69 CHRM2 (0.43) KDM1AMAPTACHEHTR2ACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1846400-A2 TRICYCLIC DELTA-OPIOID MODULATORS JANSSEN PHARMACEUTICA N.V. (BE) 2007-10-24 EP claimed
WO-2006074388-A2 TRICYCLIC δ-OPIOID MODULATORS JANSSEN PHARMACEUTICA N.V. (BE) 2006-07-13 WO claimed
EP-1846400-A2 TRICYCLIC DELTA-OPIOID MODULATORS JANSSEN PHARMACEUTICA N.V. (BE) 2007-10-24 EP disclosed
WO-2006074388-A2 TRICYCLIC δ-OPIOID MODULATORS JANSSEN PHARMACEUTICA N.V. (BE) 2006-07-13 WO disclosed