Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PRKCI | P41743 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | PTPN5 | P54829 | 4/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | GCGR | P47871 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2041153 | 0.80 | DPP4 (0.47) | KCNA5KCNH2MAPK14PIK3CDPRKCI | |
| SCHEMBL23175855 | 0.77 | PRMT6 (0.35) | KCNA5KCNH2PIK3CDPRKCIIDO1 | |
| SCHEMBL27190814 | 0.73 | AKR1B1 (0.32) | — | |
| SCHEMBL1807270 | 0.71 | CES2 (0.39) | IDO1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3637569 | 0.71 | NPC1 (0.46) | MAPK14PIK3CDRAB9ANPC1PKM | |
| SCHEMBL3904012 | 0.71 | CYP46A1 (0.36) | MAPK14IDO1ALDH1A1KMT2AMAPT | |
| SCHEMBL27893591 | 0.71 | ROCK1 (0.41) | ALDH1A1KMT2AMAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL27893610 | 0.71 | GPBAR1 (0.38) | KCNA5KCNH2MAPK14PTPN5 | |
| SCHEMBL2039805 | 0.71 | ROCK2 (0.41) | MAPK14PRKCIKMT2AHSD17B10 | |
| SCHEMBL1980395 | 0.70 | CES2 (0.38) | IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773772-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2007-04-18 | — | — | EP | disclosed |
| WO-2005121087-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2005-12-22 | — | — | WO | disclosed |