Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A12 | P48065 | 2/20 | 0.47 |
| ▸ | SLC6A13 | Q9NSD5 | 2/20 | 0.47 |
| ▸ | ACHE | P22303 | 4/20 | 0.46 |
| ▸ | BCHE | P06276 | 2/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5116402 | 0.90 | SIGMAR1 (0.45) | OPRM1OPRK1OPRL1SIGMAR1DRD4 | |
| SCHEMBL5117986 | 0.90 | OPRD1 (0.49) | OPRM1OPRK1OPRD1 | |
| SCHEMBL5115820 | 0.88 | SLC6A12 (0.52) | SLC6A12SLC6A13ACHEBCHEOPRM1 | |
| SCHEMBL5126292 | 0.87 | KDM4E (0.49) | SLC6A12SLC6A13ACHESIGMAR1ALDH1A1 | |
| SCHEMBL14000446 | 0.83 | OPRD1 (0.53) | OPRM1OPRK1OPRD1 | |
| SCHEMBL5112877 | 0.82 | PARP1 (0.47) | OPRM1OPRK1OPRL1SIGMAR1DRD4 | |
| SCHEMBL5114230 | 0.81 | OPRD1 (0.52) | OPRM1OPRK1OPRD1 | |
| SCHEMBL5126312 | 0.81 | OPRD1 (0.46) | SLC6A12SLC6A13ACHEBCHEOPRM1 | |
| SCHEMBL5118069 | 0.80 | ALDH1A1 (0.47) | SLC6A12SLC6A13OPRM1OPRK1SIGMAR1 | |
| SCHEMBL5121380 | 0.79 | OPRD1 (0.50) | OPRM1OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846400-A2 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006074388-A2 | TRICYCLIC δ-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-07-13 | — | — | WO | disclosed |