SCHEMBL5505186

SCHEMBL5505186

COc1ccc2c(c1)CC(CCc1ccccc1)O2

nearest known ligand 0.55

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 2/20 0.55
CYP3A4 P08684 1/20 0.52
DRD2 P14416 1/20 0.46
DRD4 P21917 1/20 0.46
DRD3 P35462 1/20 0.46
ABCB1 P08183 1/20 0.45
AR P10275 1/20 0.45
ABCG2 Q9UNQ0 1/20 0.45
GABRA1 P14867 1/20 0.44
GABRB2 P47870 1/20 0.44
GRIN1 Q05586 1/20 0.44
GRIN2B Q13224 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5501181 0.82 HRH3 (0.43) HRH3CYP3A4
SCHEMBL14435045 0.82 ALOX15 (0.44) CYP3A4
SCHEMBL8036686 0.81 HRH3 (0.60) HRH3DRD2DRD3ABCB1AR
Methylamine SCHEMBL10700886 0.80 HRH3 (0.59) HRH3DRD2DRD4DRD3ABCB1
SCHEMBL5502112 0.80 DRD2 (0.45) CYP3A4DRD2DRD4DRD3
SCHEMBL13802286 0.79 FFAR1 (0.56) HRH3GABRA1GABRB2
SCHEMBL14435037 0.78 CYP3A4 (0.49) HRH3CYP3A4
SCHEMBL7288358 0.78 HRH3 (0.49) HRH3CYP3A4ABCB1ARABCG2
SCHEMBL9117533 0.77 HRH3 (0.63) HRH3DRD2DRD3ABCB1AR
SCHEMBL177102 0.77 CYP26A1 (0.47) HRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070202547-A1 Methods For Detecting Substances Which Bind To The Amyloid Precursor Protein Or Beta Amyloid Fragments, And Binding Compounds MERCK & CO., INC. 2007-08-30 US disclosed
US-20070202547-A1 Methods For Detecting Substances Which Bind To The Amyloid Precursor Protein Or Beta Amyloid Fragments, And Binding Compounds MERCK & CO., INC. 2007-08-30 US disclosed
US-20070202547-A1 Methods For Detecting Substances Which Bind To The Amyloid Precursor Protein Or Beta Amyloid Fragments, And Binding Compounds MERCK & CO., INC. 2007-08-30 US disclosed
EP-1743170-A2 METHODS FOR DETECTING SUBSTANCES WHICH BIND TO THE AMYLOID PRECURSOR PROTEIN OR BETA AMYLOID FRAGMENTS, AND BINDING COMPOUNDS Merck & Co., Inc. (US) 2007-01-17 EP disclosed
WO-2005096730-A2 METHODS FOR DETECTING SUBSTANCES WHICH BIND TO THE AMYLOID PRECURSOR PROTEIN OR BETA AMYLOID FRAGMENTS, AND BINDING COMPOUNDS MERCK & CO., INC. (US) 2005-10-20 WO disclosed
US-5091533-A Treating allergies, cardiovascular disorders, inflammation MERCK FROSST CANADA, INC. (CA) 1992-02-25 US disclosed
EP-0447189-A1 5-Hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors MERCK FROSST CANADA INC. (CA) 1991-09-18 EP disclosed