Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 3/20 | 0.36 |
| ▸ | DRD2 | P14416 | 14/20 | 0.36 |
| ▸ | HTR2A | P28223 | 10/20 | 0.36 |
| ▸ | HTR1A | P08908 | 9/20 | 0.36 |
| ▸ | DRD3 | P35462 | 7/20 | 0.35 |
| ▸ | HTR2C | P28335 | 3/20 | 0.34 |
| ▸ | DRD1 | P21728 | 2/20 | 0.34 |
| ▸ | DRD4 | P21917 | 2/20 | 0.34 |
| ▸ | HTR2B | P41595 | 2/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5532366 | 1.00 | P2RX7 (0.36) | P2RX7DRD2HTR2AHTR1ADRD3 | |
| SCHEMBL5503520 | 0.87 | DRD2 (0.40) | DRD2HTR2AHTR1ADRD3HTR2C | |
| SCHEMBL5509702 | 0.84 | DRD2 (0.37) | DRD2HTR2AHTR1ADRD3DRD4 | |
| SCHEMBL5504086 | 0.83 | DRD2 (0.35) | DRD2HTR2AHTR1ADRD3DRD4 | |
| SCHEMBL5502634 | 0.82 | DRD2 (0.45) | DRD2HTR2AHTR1ADRD3HTR2C | |
| SCHEMBL5525414 | 0.79 | DRD2 (0.39) | DRD2HTR2AHTR1ADRD3HTR2C | |
| SCHEMBL5503076 | 0.78 | DRD2 (0.38) | DRD2HTR2AHTR1ADRD3HTR2C | |
| SCHEMBL5500490 | 0.78 | DRD4 (0.34) | DRD2HTR2AHTR1ADRD3HTR2C | |
| SCHEMBL5505222 | 0.76 | DRD2 (0.48) | DRD2HTR2AHTR1ADRD3HTR2C | |
| SCHEMBL5530772 | 0.75 | DRD2 (0.35) | DRD2HTR2AHTR1ADRD3HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773772-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2007-04-18 | — | — | EP | disclosed |
| WO-2005121087-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2005-12-22 | — | — | WO | disclosed |