Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.69 |
| ▸ | NPC1 | O15118 | 5/20 | 0.66 |
| ▸ | RAB9A | P51151 | 5/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.63 |
| ▸ | TP53 | P04637 | 4/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | HPGD | P15428 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | CASP1 | P29466 | 1/20 | 0.63 |
| ▸ | CASP7 | P55210 | 1/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | STAT1 | P42224 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4472849 | 0.93 | ALDH1A1 (0.70) | HTR1ANPC1RAB9AALDH1A1TP53 | |
| SCHEMBL4485908 | 0.81 | RAB9A (0.69) | HTR1ANPC1RAB9AALDH1A1MAPT | |
| SCHEMBL3090713 | 0.81 | POLB (0.77) | HTR1ANPC1RAB9AALDH1A1MAPT | |
| SCHEMBL4038422 | 0.80 | NPC1 (1.00) | NPC1RAB9AALDH1A1TP53MAPT | |
| SCHEMBL14982135 | 0.78 | NPC1 (0.77) | NPC1RAB9AALDH1A1TP53MAPT | |
| SCHEMBL2742812 | 0.78 | NPC1 (0.96) | NPC1RAB9AALDH1A1TP53MAPT | |
| SCHEMBL11832194 | 0.78 | HTR1A (0.65) | HTR1AALDH1A1MAPTHPGDTSHR | |
| SCHEMBL10605457 | 0.77 | RAB9A (0.61) | NPC1RAB9AALDH1A1TP53MAPT | |
| SCHEMBL11763488 | 0.77 | RAB9A (0.61) | NPC1RAB9AALDH1A1TP53MAPT | |
| SCHEMBL4432092 | 0.77 | HDAC1 (0.63) | HTR1ANPC1RAB9AALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848692-A1 | AZOLYLACYLGUANIDINES AS ß-SECRETASE INHIBITORS | Wyeth (US) | 2007-10-31 | — | — | EP | disclosed |
| WO-2006088711-A1 | AZOLYLACYLGUANIDINES AS β-SECRETASE INHIBITORS | WYETH (US) | 2006-08-24 | — | — | WO | disclosed |