Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | CYBB | P04839 | 1/20 | 0.33 |
| ▸ | NOX5 | Q96PH1 | 1/20 | 0.33 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.33 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3700174 | 0.76 | HSD11B1 (0.46) | NOTUMHSD11B1MCHR1USP30 | |
| SCHEMBL2703017 | 0.76 | HSD11B1 (0.46) | NOTUMHSD11B1MCHR1USP30 | |
| SCHEMBL550592 | 0.68 | USP30 (0.57) | MEN1KMT2AHSD11B1CYBBNOX5 | |
| SCHEMBL18192079 | 0.66 | KCNJ1 (0.35) | — | |
| SCHEMBL20142342 | 0.65 | NOTUM (0.51) | MEN1KMT2ACRHBPCRHR2NOTUM | |
| SCHEMBL20139276 | 0.64 | AKR1C3 (0.57) | MEN1KMT2ANOTUMHTR7ALDH1A1 | |
| SCHEMBL2857040 | 0.63 | AKR1C3 (0.64) | MEN1KMT2ANOTUMHTR7ALDH1A1 | |
| SCHEMBL17081996 | 0.62 | AKR1C3 (0.46) | MEN1KMT2ANOTUMHSD11B1HTR7 | |
| SCHEMBL550501 | 0.62 | AKR1C3 (0.46) | MEN1KMT2ANOTUMHSD11B1HTR7 | |
| SCHEMBL550502 | 0.62 | AKR1C3 (0.46) | MEN1KMT2ANOTUMHSD11B1HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110581-B2 | Lactam compounds and their use as pharmaceuticals | INCYTE CORPORATION (US) | 2012-02-07 | — | — | US | disclosed |