Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 5/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | AR | P10275 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5500813 | 0.84 | AR (0.56) | ALDH1A1LMNANPC1RAB9AMAPT | |
| SCHEMBL5114340 | 0.83 | AR (0.60) | ALDH1A1LMNANPC1RAB9AMAPT | |
| SCHEMBL5534689 | 0.77 | AR (0.52) | ALDH1A1LMNANPC1RAB9AMAPT | |
| SCHEMBL5120902 | 0.75 | PTGDR2 (0.61) | KMT2APOLB | |
| SCHEMBL2798824 | 0.73 | SMN1; SMN2 (0.47) | ALDH1A1NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL9514166 | 0.73 | ALDH1A1 (1.00) | ALDH1A1LMNANPC1RAB9AMAPT | |
| SCHEMBL3542412 | 0.73 | LMNA (0.72) | ALDH1A1LMNANPC1RAB9AMAPT | |
| SCHEMBL5121197 | 0.72 | PTGDR2 (0.40) | LMNAMAPTKMT2A | |
| SCHEMBL10685902 | 0.72 | LMNA (0.80) | ALDH1A1LMNANPC1RAB9AMAPT | |
| SCHEMBL25973444 | 0.72 | TP53 (0.43) | ALDH1A1NPC1RAB9ASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784182-A1 | 2-SULFANYL-BENZIMIDAZOL-1-YL-ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006021418-A1 | 2-SULFANYL-BENZOIMIDAZOL-1-YL-ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-03-02 | — | — | WO | disclosed |