Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 7/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5114340 | 0.92 | AR (0.60) | ARBCHEALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL5500813 | 0.84 | AR (0.56) | ARBCHEALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL5504394 | 0.78 | AR (0.58) | ARALDH1A1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL5506178 | 0.77 | ALDH1A1 (0.57) | ARBCHEALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL5499298 | 0.74 | AR (0.63) | ARBCHEALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6440551 | 0.72 | BCHE (0.61) | BCHEALDH1A1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL6304380 | 0.71 | BCHE (0.69) | BCHEALDH1A1SMN1; SMN2MAPTLMNA | |
| SCHEMBL5503614 | 0.71 | AR (0.66) | ARALDH1A1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL5106826 | 0.70 | PTGDR2 (0.68) | KMT2A | |
| SCHEMBL572740 | 0.70 | IDO1 (0.60) | ALDH1A1MAPTGAANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784182-A1 | 2-SULFANYL-BENZIMIDAZOL-1-YL-ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006021418-A1 | 2-SULFANYL-BENZOIMIDAZOL-1-YL-ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-03-02 | — | — | WO | disclosed |