Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5114340 | 0.91 | AR (0.60) | ARALDH1A1LMNASMN1; SMN2MAPT | |
| SCHEMBL5534689 | 0.84 | AR (0.52) | ARALDH1A1LMNASMN1; SMN2MAPT | |
| SCHEMBL5506178 | 0.84 | ALDH1A1 (0.57) | ARALDH1A1LMNASMN1; SMN2MAPT | |
| SCHEMBL5504394 | 0.76 | AR (0.58) | ARALDH1A1LMNASMN1; SMN2MAPT | |
| SCHEMBL5121162 | 0.76 | PTGDR2 (0.64) | KMT2APOLB | |
| SCHEMBL8915903 | 0.75 | RAB9A (0.46) | ARALDH1A1LMNASMN1; SMN2MAPT | |
| SCHEMBL5736847 | 0.75 | HDAC3 (0.51) | LMNASMN1; SMN2MAPTNPC1MAPK1 | |
| SCHEMBL5737640 | 0.75 | HDAC1 (0.54) | LMNA | |
| SCHEMBL5111621 | 0.74 | AR (0.61) | ARALDH1A1LMNASMN1; SMN2MAPT | |
| SCHEMBL8525848 | 0.74 | HDAC3 (0.56) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784182-A1 | 2-SULFANYL-BENZIMIDAZOL-1-YL-ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006021418-A1 | 2-SULFANYL-BENZOIMIDAZOL-1-YL-ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-03-02 | — | — | WO | disclosed |