SCHEMBL550622

SCHEMBL550622

COC(=O)c1ccc(C(F)(F)C(F)(F)F)c(C(F)(F)C(F)(F)F)c1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 3/20 0.59
CA1 P00915 3/20 0.49
CA2 P00918 3/20 0.49
CA12 O43570 2/20 0.49
CA7 P43166 2/20 0.49
CA9 Q16790 2/20 0.49
CA14 Q9ULX7 2/20 0.49
XDH P47989 1/20 0.49
PDK2 Q15119 4/20 0.46
PDK1 Q15118 2/20 0.46
PDK3 Q15120 2/20 0.46
PDK4 Q16654 2/20 0.46
KDM4E B2RXH2 5/20 0.45
ALDH1A1 P00352 3/20 0.45
MAPT P10636 3/20 0.45
HPGD P15428 2/20 0.45
HSD17B10 Q99714 2/20 0.45
GLA P06280 1/20 0.45
GAA P10253 1/20 0.45
CASP1 P29466 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1997248 0.82 NOTUM (0.73) NOTUMCA1CA2CA12CA7
SCHEMBL10907300 0.77 NOTUM (0.66) NOTUMCA1CA2CA12CA7
SCHEMBL5361981 0.77 NOTUM (0.56) NOTUMCA1CA2CA12CA7
SCHEMBL5355256 0.77 NOTUM (0.56) NOTUMCA1CA2CA12CA7
SCHEMBL13440125 0.77 NOTUM (0.56) NOTUMCA1CA2CA12CA7
SCHEMBL14012580 0.76 NOTUM (0.64) NOTUMCA1CA2CA12CA7
SCHEMBL399738 0.76 P4HB (0.66) NOTUMCA1CA2CA12CA7
SCHEMBL10861732 0.76 NOTUM (0.64) NOTUMCA1CA2CA12CA7
SCHEMBL321308 0.76 NOTUM (0.79) NOTUMCA1CA2CA12CA7
SCHEMBL3902096 0.76 NOTUM (0.69) NOTUMCA1CA2CA12CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8110689-B2 Benzanilides with insecticidal activity BAYER CROPSCIENE AG (DE) 2012-02-07 US disclosed
US-20100062937-A1 BENZANILIDES WITH INSECTICIDAL ACTIVITY BAYER CROPSCIENCE AG (DE) 2010-03-11 US disclosed
EP-1893567-A1 BENZANILIDES WITH INSECTICIDAL ACTIVITY Bayer CropScience AG (DE) 2008-03-05 EP disclosed
WO-2006133823-A1 BENZANILIDES WITH INSECTICIDAL ACTIVITY BAYER CROPSCIENCE AG (DE) 2006-12-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100062937-A1 BENZANILIDES WITH INSECTICIDAL ACTIVITY CBR3, HCN3, HAX1 NOTUM 773/4885CA1 3291/4885CA2 849/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.