Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 7/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | PGR | P06401 | 3/20 | 0.47 |
| ▸ | AR | P10275 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8674574 | 1.00 | NR3C1 (0.70) | NR3C1CYP3A4PGRARUSP2 | |
| SCHEMBL7894324 | 0.95 | NR3C1 (0.68) | NR3C1CYP3A4PGRARUSP2 | |
| SCHEMBL8138913 | 0.94 | NR3C1 (0.66) | NR3C1CYP3A4PGRARUSP2 | |
| Rofleponide SCHEMBL8505525 | 0.93 | NR3C1 (0.68) | NR3C1CYP3A4PGRARLMNA | |
| Rofleponide SCHEMBL5506220 | 0.93 | NR3C1 (0.68) | NR3C1CYP3A4PGRARLMNA | |
| Rofleponide SCHEMBL23803954 | 0.93 | NR3C1 (0.68) | NR3C1CYP3A4PGRARLMNA | |
| Rofleponide SCHEMBL7196822 | 0.93 | NR3C1 (0.68) | NR3C1CYP3A4PGRARLMNA | |
| Rofleponide SCHEMBL74762 | 0.93 | NR3C1 (0.68) | NR3C1CYP3A4PGRARLMNA | |
| SCHEMBL8204804 | 0.92 | NR3C1 (0.67) | NR3C1CYP3A4PGRARUSP2 | |
| Rofleponide SCHEMBL6449744 | 0.90 | NR3C1 (0.64) | NR3C1CYP3A4PGRARLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173430-B1 | ENANTIOMERS OF MERCAPTO LACTONES AND PROCESSES FOR THEIR SYNTHESIS | GLAXO GROUP LTD (GB) | 2003-07-09 | — | — | EP | disclosed |
| EP-1173430-A1 | ENANTIOMERS OF MERCAPTO LACTONES AND PROCESSES FOR THEIR SYNTHESIS | GLAXO GROUP LIMITED (GB) | 2002-01-23 | — | — | EP | disclosed |
| US-6197761-B1 | ANTIINFLAMMATORY, ANTALLERGEN AGENTS | GLAXO WELLCOME INC. | 2001-03-06 | — | — | US | disclosed |
| WO-2000064882-A2 | ENANTIOMERS OF MERCAPTO LACTONES AND PROCESSES FOR THEIR SYNTHESIS | GLAXO GROUP LIMITED (GB) | 2000-11-02 | — | — | WO | disclosed |
| US-6114318-A | ANTIINFLAMMATORY AGENT, ANTIALLERGENS | GLAXO GROUP LIMITED (GB) | 2000-09-05 | — | — | US | disclosed |
| EP-0883628-B1 | 17BETA-(2-OXO-TETRAHYDROFURAN-4-YL)-THIO-ANDROSTANE DERIVATIVES (17BETA-(GAMMA-BUTYRIC ACID LACTONE)-THIO DERIVATIVES) FOR THE TREATMENT OF INFLAMMATION AND PHARMACEUTICAL COMPOSITIONS AND A PROCESS FOR THE PRODUCTION THEREOF | GLAXO GROUP LTD (GB) | 2000-08-16 | — | — | EP | disclosed |
| EP-0876392-B1 | LACTONE DERIVATIVES OF 17.BETA.-CARBOXY, CARBOTHIO AND AMIDE ANDROSTANE DERIVATIVES | GLAXO GROUP LTD (GB) | 2000-07-05 | — | — | EP | disclosed |
| EP-0883628-A1 | 17BETA-(2-OXO-TETRAHYDROFURAN-4-YL)-THIO-ANDROSTANE DERIVATIVES (17BETA-(GAMMA-BUTYRIC ACID LACTONE)-THIO DERIVATIVES) FOR THE TREATMENT OF INFLAMMATION AND PHARMACEUTICAL COMPOSITIONS AND A PROCESS FOR THE PRODUCTION THEREOF | GLAXO GROUP LIMITED (GB) | 1998-12-16 | — | — | EP | disclosed |
| EP-0876392-A1 | LACTONE DERIVATIVES OF 17.BETA.-CARBOXY, CARBOTHIO AND AMIDE ANDROSTANE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997024368-A1 | 17BETA-(2-OXO-TETRAHYDROFURAN-4-YL)-THIO-ANDROSTANE DERIVATIVES (17BETA-(GAMMA-BUTYRIC ACID LACTONE)-THIO DERIVATIVES) FOR THE TREATMENT OF INFLAMMATION AND PHARMACEUTICAL COMPOSITIONS AND A PROCESS FOR THE PRODUCTION THEREOF | GLAXO GROUP LIMITED (GB) | 1997-07-10 | — | — | WO | disclosed |
| WO-1997024365-A1 | LACTONE DERIVATIVES OF 17.BETA.-CARBOXY, CARBOTHIO AND AMIDE ANDROSTANE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1997-07-10 | — | — | WO | disclosed |