Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 9/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | PGR | P06401 | 2/20 | 0.49 |
| ▸ | AR | P10275 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.47 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | IL5 | P05113 | 1/20 | 0.47 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rofleponide SCHEMBL23803954 | 0.97 | NR3C1 (0.68) | NR3C1CYP3A4LMNAHIF1AHSD17B10 | |
| Rofleponide SCHEMBL7196822 | 0.97 | NR3C1 (0.68) | NR3C1CYP3A4LMNAHIF1AHSD17B10 | |
| Rofleponide SCHEMBL5506220 | 0.97 | NR3C1 (0.68) | NR3C1CYP3A4LMNAHIF1AHSD17B10 | |
| Rofleponide SCHEMBL74762 | 0.97 | NR3C1 (0.68) | NR3C1CYP3A4LMNAHIF1AHSD17B10 | |
| Rofleponide SCHEMBL8505525 | 0.97 | NR3C1 (0.68) | NR3C1CYP3A4LMNAHIF1AHSD17B10 | |
| SCHEMBL8204804 | 0.90 | NR3C1 (0.67) | NR3C1CYP3A4LMNAHIF1AHSD17B10 | |
| SCHEMBL7081817 | 0.90 | NR3C1 (0.70) | NR3C1CYP3A4LMNAHIF1AHSD17B10 | |
| SCHEMBL8674574 | 0.90 | NR3C1 (0.70) | NR3C1CYP3A4LMNAHIF1AHSD17B10 | |
| SCHEMBL6323559 | 0.90 | NR3C1 (0.57) | NR3C1CYP3A4LMNAHIF1AHSD17B10 | |
| SCHEMBL8138913 | 0.89 | NR3C1 (0.66) | NR3C1CYP3A4LMNAHIF1AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050032760-A1 | Continuous process for the production of r-rofleponide | ALSTEN JOHN GREGG VAN (US) | 2005-02-10 | — | — | US | claimed |
| WO-2004074306-A1 | A CONTINUOUS PROCESS FOR THE PRODUCTION OF R-ROFLEPONIDE | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-09-02 | — | — | WO | claimed |
| US-20050032760-A1 | Continuous process for the production of r-rofleponide | ALSTEN JOHN GREGG VAN (US) | 2005-02-10 | — | — | US | disclosed |
| WO-2004074306-A1 | A CONTINUOUS PROCESS FOR THE PRODUCTION OF R-ROFLEPONIDE | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050032760-A1 | Continuous process for the production of r-rofleponide | CYP17A1, HSD17B7, NR3C2 | NR3C1 19/4885CYP3A4 62/4885LMNA 4256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.