Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 2/20 | 0.43 |
| ▸ | USP5 | P45974 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2155207 | 0.86 | MMP3 (0.46) | MMP3USP5KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL27713628 | 0.85 | MMP3 (0.43) | MMP3USP5KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL2154896 | 0.84 | MMP3 (0.48) | MMP3USP5KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL2154893 | 0.83 | MMP3 (0.39) | MMP3USP5KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL5509222 | 0.80 | MMP3 (0.50) | MMP3USP5KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL2156697 | 0.76 | MMP3 (0.44) | MMP3USP5KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL2154948 | 0.76 | MMP3 (0.46) | MMP3USP5ALDH1A1SMN1; SMN2HSD17B2 | |
| SCHEMBL2155627 | 0.76 | MMP3 (0.48) | MMP3USP5ALDH1A1NPC1RAB9A | |
| SCHEMBL16493552 | 0.75 | MMP3 (0.46) | MMP3USP5KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL16994786 | 0.74 | LMNA (0.56) | MMP3USP5KDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828160-A1 | SULFONYL AMINO CYCLIC DERIVATIVES AND USE THEREOF AS MMP INHIBITORS | LABORATOIRES SERONO S.A. (CH) | 2007-09-05 | — | — | EP | claimed |
| WO-2006067114-A1 | SULFONYL AMINO CYCLIC DERIVATIVES AND USE THEREOF | LABORATOIRES SERONO S.A. (CH) | 2006-06-29 | — | — | WO | claimed |
| EP-1828160-A1 | SULFONYL AMINO CYCLIC DERIVATIVES AND USE THEREOF AS MMP INHIBITORS | LABORATOIRES SERONO S.A. (CH) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006067114-A1 | SULFONYL AMINO CYCLIC DERIVATIVES AND USE THEREOF | LABORATOIRES SERONO S.A. (CH) | 2006-06-29 | — | — | WO | disclosed |