Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.48 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.48 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.43 |
| ▸ | MLYCD | O95822 | 1/20 | 0.43 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.42 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | ABAT | P80404 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | DDR1 | Q08345 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5510200 | 0.96 | TAS1R3 (0.47) | TAS1R3TAS1R1TAS1R2HTR4CACNA1H | |
| SCHEMBL3773845 | 0.85 | TAS1R3 (0.48) | TAS1R3TAS1R1TAS1R2CACNA1HHTR2A | |
| SCHEMBL5513140 | 0.82 | HDAC6 (0.51) | TAS1R3TAS1R1TAS1R2HDAC6ALDH1A1 | |
| SCHEMBL3770718 | 0.79 | KCNH2 (0.45) | TAS1R3TAS1R1TAS1R2CACNA1HHTR2A | |
| SCHEMBL708326 | 0.79 | TAS1R3 (0.50) | TAS1R3TAS1R1TAS1R2CACNA1HEPHX2 | |
| Hydrochloric Acid SCHEMBL711109 | 0.78 | TAS1R3 (0.49) | TAS1R3TAS1R1TAS1R2CACNA1HEPHX2 | |
| SCHEMBL3763868 | 0.78 | SLC6A9 (0.51) | TAS1R3TAS1R1TAS1R2HDAC6HTR4 | |
| SCHEMBL5506741 | 0.78 | JAK2 (0.43) | — | |
| SCHEMBL3776688 | 0.78 | CCR2 (0.49) | HTR4ALDH1A1KCNH2 | |
| SCHEMBL5511226 | 0.77 | SLC6A9 (0.50) | TAS1R3TAS1R1TAS1R2HDAC6HTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869019-B1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PROD INC (US) | 2014-08-27 | — | — | EP | claimed |
| EP-1869019-A1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | Pfizer Products Incorporated (US) | 2007-12-26 | — | — | EP | claimed |
| WO-2006106425-A1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PRODUCTS INC. (US) | 2006-10-12 | — | — | WO | claimed |
| EP-1869019-B1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PROD INC (US) | 2014-08-27 | — | — | EP | disclosed |