Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 3/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.49 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.49 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.49 |
| ▸ | CCR2 | P41597 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.43 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3763868 | 0.99 | SLC6A9 (0.51) | SLC6A9KCNH2HDAC6TAS1R3TAS1R1 | |
| SCHEMBL3765783 | 0.95 | SLC6A9 (0.49) | SLC6A9KCNH2HDAC6TAS1R3TAS1R1 | |
| SCHEMBL5505965 | 0.85 | HPGD (0.56) | TAS1R3TAS1R1TAS1R2CCR2MEN1 | |
| SCHEMBL15967222 | 0.85 | CCR2 (0.52) | SLC6A9HDAC6TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL5507358 | 0.85 | TAS1R3 (0.52) | SLC6A9HDAC6TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL5506744 | 0.85 | NAMPT (0.49) | SLC6A9KCNH2TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL15967196 | 0.84 | CCR2 (0.53) | HDAC6TAS1R3TAS1R1TAS1R2CCR2 | |
| SCHEMBL5513140 | 0.84 | HDAC6 (0.51) | KCNH2HDAC6TAS1R3TAS1R1TAS1R2 | |
| Hydrochloric Acid SCHEMBL710199 | 0.84 | NAMPT (0.48) | SLC6A9KCNH2TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL5512495 | 0.83 | POLB (0.48) | SLC6A9TAS1R3TAS1R1TAS1R2CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869019-B1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PROD INC (US) | 2014-08-27 | — | — | EP | claimed |
| EP-1869019-A1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | Pfizer Products Incorporated (US) | 2007-12-26 | — | — | EP | claimed |
| WO-2006106425-A1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PRODUCTS INC. (US) | 2006-10-12 | — | — | WO | claimed |
| EP-1869019-B1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PROD INC (US) | 2014-08-27 | — | — | EP | disclosed |