Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | USP5 | P45974 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | ACLY | P53396 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5510215 | 0.84 | DRD2 (0.52) | MMP3DRD2USP5CHRM2CHRM1 | |
| SCHEMBL5500882 | 0.84 | LMNA (0.46) | DRD2ALDH1A1THRBMAPTSMN1; SMN2 | |
| SCHEMBL5510208 | 0.81 | DRD2 (0.46) | MMP3DRD2USP5CHRM2CHRM1 | |
| SCHEMBL2156142 | 0.79 | DRD2 (0.42) | MMP3DRD2USP5CHRM2CHRM1 | |
| SCHEMBL27693729 | 0.78 | DRD2 (0.41) | MMP3DRD2USP5CHRM2CHRM1 | |
| SCHEMBL5506031 | 0.77 | THRB (0.46) | DRD2ALDH1A1THRBMAPTSMN1; SMN2 | |
| SCHEMBL2155714 | 0.77 | MMP3 (0.43) | MMP3DRD2USP5CHRM2CHRM1 | |
| SCHEMBL2155404 | 0.77 | DRD2 (0.46) | DRD2USP5CHRM2CHRM1ACLY | |
| SCHEMBL2155400 | 0.77 | DRD2 (0.46) | DRD2USP5CHRM2CHRM1ACLY | |
| SCHEMBL2155707 | 0.76 | DRD2 (0.39) | MMP3DRD2USP5CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828160-A1 | SULFONYL AMINO CYCLIC DERIVATIVES AND USE THEREOF AS MMP INHIBITORS | LABORATOIRES SERONO S.A. (CH) | 2007-09-05 | — | — | EP | claimed |
| WO-2006067114-A1 | SULFONYL AMINO CYCLIC DERIVATIVES AND USE THEREOF | LABORATOIRES SERONO S.A. (CH) | 2006-06-29 | — | — | WO | claimed |