Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT1 | P04628 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 11/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 9/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 2/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5499996 | 0.92 | CNR1 (0.38) | WNT1DYRK1ACNR1CYP11B1CYP11B2 | |
| Hydrochloric Acid SCHEMBL5504549 | 0.91 | CNR1 (0.38) | WNT1DYRK1ACNR1CYP11B1CYP11B2 | |
| SCHEMBL5500821 | 0.89 | CNR1 (0.38) | WNT1DYRK1ACNR1CYP11B1CYP11B2 | |
| SCHEMBL5504107 | 0.84 | CYP11B2 (0.41) | CNR1CYP11B1CYP11B2CYP1A2HCRTR1 | |
| Hydrochloric Acid SCHEMBL5504176 | 0.83 | CYP11B2 (0.40) | CNR1CYP11B1CYP11B2CYP1A2HCRTR1 | |
| SCHEMBL5506141 | 0.81 | CD38 (0.35) | CCR5 | |
| SCHEMBL5499959 | 0.80 | CYP11B1 (0.38) | CNR1CYP11B1CYP11B2CYP1A2HCRTR1 | |
| SCHEMBL5506180 | 0.80 | AAK1 (0.34) | HCRTR1HCRTR2CCR5MCHR1 | |
| SCHEMBL5504170 | 0.80 | CNR1 (0.36) | CNR1CYP11B1CYP11B2CCR5 | |
| SCHEMBL5504232 | 0.80 | CTSS (0.36) | CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-07-18 | — | — | EP | claimed |
| WO-2006049952-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-05-11 | — | — | WO | claimed |
| EP-1807072-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006049952-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-05-11 | — | — | WO | disclosed |