SCHEMBL5508293

SCHEMBL5508293

Nc1c(O)ccc(C(F)(F)F)c1C(F)(F)F

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GLA P06280 2/20 0.34
POLB P06746 2/20 0.34
GAA P10253 2/20 0.34
TSHR P16473 1/20 0.34
KIF11 P52732 3/20 0.33
HSD17B1 P14061 2/20 0.32
HSD17B2 P37059 2/20 0.32
USP7 Q93009 1/20 0.31
KDM4E B2RXH2 1/20 0.31
MEN1 O00255 1/20 0.31
ALDH1A1 P00352 1/20 0.31
MAPT P10636 1/20 0.31
HPGD P15428 1/20 0.31
KMT2A Q03164 1/20 0.31
ATM Q13315 1/20 0.31
HSD17B10 Q99714 1/20 0.31
CES2 O00748 1/20 0.31
TMPRSS4 Q9NRS4 1/20 0.30
CSNK2A2 P19784 1/20 0.30
CSNK2B P67870 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5042959 0.86 ALDH1A1 (0.33) GAAMEN1ALDH1A1MAPTKMT2A
SCHEMBL1773087 0.86 ESR1 (0.33) GLAPOLBGAAKDM4EMEN1
SCHEMBL5515872 0.83 GLA (0.34) GLAPOLBGAATSHRKIF11
SCHEMBL25013343 0.81 POLB (0.39) GLAPOLBGAATSHRKIF11
SCHEMBL30632227 0.81 POLB (0.39) GLAPOLBGAATSHRKIF11
SCHEMBL5042495 0.80 POLB (0.37) GLAPOLBGAATSHRUSP7
SCHEMBL15727006 0.80
SCHEMBL21835028 0.80 MEN1 (0.30) POLBMEN1ALDH1A1MAPTKMT2A
SCHEMBL4542512 0.79 KIF11 (0.36) KIF11HSD17B1HSD17B2MEN1KMT2A
SCHEMBL30368280 0.79 KIF11 (0.36) KIF11HSD17B1HSD17B2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7208559-B2 Ethylened polymer and molded object obtained therefrom MITSUI CHEMICALS, INC. (JP) 2007-04-24 US disclosed
US-20060135712-A1 Ethylened polymer and molded object obtained therefrom MITSUI CHEMICALS, INC. (JP) 2006-06-22 US disclosed
US-4731450-A Process for perfluoroalkylation of aromatic derivatives RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1988-03-15 US disclosed