Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCAT2 | O15382 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | BCL2 | P10415 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | MME | P08473 | 1/20 | 0.34 |
| ▸ | ACE | P12821 | 1/20 | 0.34 |
| ▸ | CPA1 | P15085 | 1/20 | 0.34 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 4/20 | 0.34 |
| ▸ | CA1 | P00915 | 3/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5508581 | 1.00 | BCAT2 (0.42) | BCAT2HCAR2ALDH1A1HPGDBCL2 | |
| SCHEMBL2160122 | 0.81 | ALDH1A1 (0.41) | BCAT2HCAR2ALDH1A1HPGDKDM4E | |
| SCHEMBL756357 | 0.81 | ALDH1A1 (0.41) | BCAT2HCAR2ALDH1A1HPGDKDM4E | |
| SCHEMBL2160129 | 0.81 | ALDH1A1 (0.41) | BCAT2HCAR2ALDH1A1HPGDKDM4E | |
| SCHEMBL28633617 | 0.79 | BCAT2 (0.35) | BCAT2HCAR2ALDH1A1 | |
| SCHEMBL28633615 | 0.79 | BCAT2 (0.35) | BCAT2HCAR2ALDH1A1 | |
| SCHEMBL503440 | 0.78 | FDPS (0.54) | ALDH1A1HPGDKDM4E | |
| SCHEMBL29417369 | 0.78 | FDPS (0.54) | ALDH1A1HPGDKDM4E | |
| SCHEMBL44077 | 0.78 | FDPS (0.54) | ALDH1A1HPGDKDM4E | |
| SCHEMBL30410840 | 0.78 | HCAR2 (0.46) | HCAR2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773877-A1 | HUMAN GLUCAGON-LIKE-PEPTIDE-1 MODULATORS AND THEIR USE IN THE TREATMENT OF DIABETES AND RELATED CONDITIONS | Bristol-Myers Squibb Company (US) | 2007-04-18 | — | — | EP | claimed |
| WO-2006014287-A1 | HUMAN GLUCAGON-LIKE-PEPTIDE-1 MODULATORS AND THEIR USE IN THE TREATMENT OF DIABETES AND RELATED CONDITIONS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-02-09 | — | — | WO | claimed |