SCHEMBL28633617

SCHEMBL28633617

CC(Nc1cncnc1)C(=O)NN

nearest known ligand 0.35

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
BCAT2 O15382 1/20 0.35
VNN1 O95497 5/20 0.33
AAK1 Q2M2I8 1/20 0.33
ALDH1A1 P00352 2/20 0.33
MEN1 O00255 1/20 0.33
LMNA P02545 1/20 0.33
KMT2A Q03164 1/20 0.33
HCAR2 Q8TDS4 1/20 0.32
CTSD P07339 1/20 0.32
LRRK2 Q5S007 1/20 0.32
HIF1A Q16665 1/20 0.31
GAA P10253 1/20 0.31
HTT P42858 1/20 0.31
IDO1 P14902 2/20 0.30
OGG1 O15527 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28633615 1.00 BCAT2 (0.35) BCAT2VNN1AAK1ALDH1A1MEN1
SCHEMBL21834452 0.80 FDPS (0.50) ALDH1A1MEN1LMNAKMT2AHIF1A
SCHEMBL5508575 0.79 BCAT2 (0.42) BCAT2ALDH1A1HCAR2
SCHEMBL5508581 0.79 BCAT2 (0.42) BCAT2ALDH1A1HCAR2
SCHEMBL1627560 0.74 CTSD (0.50) ALDH1A1MEN1LMNAKMT2ACTSD
SCHEMBL28632158 0.72 ELANE (0.42) LMNAKMT2A
SCHEMBL12777970 0.69 KMT2A (0.47) BCAT2ALDH1A1MEN1LMNAKMT2A
SCHEMBL5516162 0.69 TDP1 (0.44) BCAT2ALDH1A1LMNALRRK2GAA
SCHEMBL756357 0.69 ALDH1A1 (0.41) BCAT2ALDH1A1MEN1LMNAKMT2A
SCHEMBL2160122 0.69 ALDH1A1 (0.41) BCAT2ALDH1A1MEN1LMNAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113348017-A Hydrazide compound and kinase inhibitor 日产化学株式会社 2021-09-03 CN disclosed