Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 12/20 | 0.77 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | TOP2A | P11388 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | FABP3 | P05413 | 1/20 | 0.39 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.39 |
| ▸ | MAT2A | P31153 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5511769 | 0.87 | ADORA3 (1.00) | ADORA3CA9ADORA2AADORA1TOP2A | |
| SCHEMBL5508801 | 0.85 | ADORA3 (0.83) | ADORA3CA9ADORA2AADORA1MAPT | |
| SCHEMBL5513775 | 0.85 | ADORA3 (0.86) | ADORA3MAPTKDM4ESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5507703 | 0.83 | ADORA3 (0.71) | ADORA3CA9ADORA2AADORA1KDM4E | |
| SCHEMBL5503114 | 0.80 | ADORA3 (1.00) | ADORA3CA9ADORA2AADORA1KDM4E | |
| SCHEMBL5503857 | 0.79 | ADORA3 (0.64) | ADORA3CA9ADORA2AADORA1KDM4E | |
| SCHEMBL14802110 | 0.71 | ADORA3 (0.55) | ADORA3CA9ADORA2AADORA1KDM4E | |
| SCHEMBL29749478 | 0.70 | MEN1 (0.63) | POLBMAPTATMKDM4ENPSR1 | |
| SCHEMBL30039386 | 0.70 | MEN1 (0.63) | POLBMAPTATMKDM4ENPSR1 | |
| SCHEMBL149177 | 0.70 | MEN1 (0.63) | POLBMAPTATMKDM4ENPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863813-A2 | PYRAZOLO[3,4-C]QUINOLINES, PYRAZOLO[3,4-C]NAPHTHYRIDINES, ANALOGS THEREOF, AND METHODS | Coley Pharmaceutical Group, Inc. (US) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006107771-A2 | PYRAZOLO[3,4-c]QUINOLINES, PYRAZOLO[3,4-c]NAPHTHYRIDINES, ANALOGS THEREOF, AND METHODS | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2006-10-12 | — | — | WO | disclosed |