Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.86 |
| ▸ | PGR | P06401 | 4/20 | 0.59 |
| ▸ | RORA | P35398 | 3/20 | 0.59 |
| ▸ | RORC | P51449 | 3/20 | 0.59 |
| ▸ | RORB | Q92753 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5511769 | 0.93 | ADORA3 (1.00) | ADORA3PGRRORARORCRORB | |
| SCHEMBL5508801 | 0.89 | ADORA3 (0.83) | ADORA3PGRALDH1A1KDM4EHPGD | |
| SCHEMBL5509727 | 0.85 | ADORA3 (0.77) | ADORA3KDM4EMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5507703 | 0.81 | ADORA3 (0.71) | ADORA3PGRKDM4ESMN1; SMN2 | |
| SCHEMBL5503114 | 0.80 | ADORA3 (1.00) | ADORA3PGRALDH1A1KDM4EHPGD | |
| SCHEMBL5503857 | 0.77 | ADORA3 (0.64) | ADORA3KDM4EHPGDCNR2SMN1; SMN2 | |
| SCHEMBL14141960 | 0.75 | RORA (1.00) | PGRRORARORCRORBALDH1A1 | |
| SCHEMBL9209736 | 0.75 | PGR (0.54) | ADORA3PGRRORARORCRORB | |
| SCHEMBL9208110 | 0.72 | PGR (0.58) | ADORA3PGRRORARORCRORB | |
| SCHEMBL29531665 | 0.72 | PGR (0.73) | PGRRORARORCRORBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863813-A2 | PYRAZOLO[3,4-C]QUINOLINES, PYRAZOLO[3,4-C]NAPHTHYRIDINES, ANALOGS THEREOF, AND METHODS | Coley Pharmaceutical Group, Inc. (US) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006107771-A2 | PYRAZOLO[3,4-c]QUINOLINES, PYRAZOLO[3,4-c]NAPHTHYRIDINES, ANALOGS THEREOF, AND METHODS | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2006-10-12 | — | — | WO | disclosed |