Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARG1 | P05089 | 1/20 | 0.47 |
| ▸ | ARG2 | P78540 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 3/20 | 0.43 |
| ▸ | NOS1 | P29475 | 2/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | BHMT | Q93088 | 6/20 | 0.33 |
| ▸ | BHMT2 | Q9H2M3 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9436829 | 1.00 | ARG1 (0.47) | ARG1ARG2NOS2NOS1NOS3 | |
| Hydrochloric Acid SCHEMBL8932134 | 0.98 | ARG1 (0.46) | ARG1ARG2NOS2NOS1NOS3 | |
| SCHEMBL7977238 | 0.87 | NOS2 (0.33) | ARG1ARG2NOS2NOS1NOS3 | |
| SCHEMBL537841 | 0.86 | BHMT (0.50) | NOS2NOS1NOS3BHMTBHMT2 | |
| SCHEMBL537840 | 0.86 | BHMT (0.50) | NOS2NOS1NOS3BHMTBHMT2 | |
| SCHEMBL6655681 | 0.86 | BHMT (0.50) | NOS2NOS1NOS3BHMTBHMT2 | |
| Phosphonic Acid SCHEMBL27587576 | 0.82 | BHMT (0.49) | NOS2NOS1NOS3BHMTBHMT2 | |
| SCHEMBL1504429 | 0.75 | GSR (0.46) | ARG1ARG2NOS2NOS1NOS3 | |
| SCHEMBL4316097 | 0.75 | GSR (0.46) | ARG1ARG2NOS2NOS1NOS3 | |
| SCHEMBL21067514 | 0.75 | GSR (0.46) | ARG1ARG2NOS2NOS1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE39576-E1 | Enzyme inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2007-04-17 | — | — | US | disclosed |
| US-5889056-A | OF NITRIC OXIDE SYNTHASE; HYPOTENSIVE AGENT, ANTIINFLAMMATORY AGENTS, ANTIARTHRITIC AGENTS | GLAXO WELLSOME INC. (US) | 1999-03-30 | — | — | US | disclosed |
| EP-0765308-A1 | ENZYME INHIBITORS | THE WELLCOME FOUNDATION LIMITED (GB) | 1997-04-02 | — | — | EP | disclosed |
| WO-1995034534-A1 | ENZYME INHIBITORS | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-12-21 | — | — | WO | disclosed |